MolNFT v1 · #168165 · protein
Structure of eed bound to inhibitor 1056
6W7G · Polycomb protein eed: “Structure of eed bound to inhibitor 1056”. X-ray diffraction, 2 ligands (Q3A, NA), 3 pockets (best druggability 0.78). MolNFT v1 #168165 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6W7G
- Type
- protein
- Length
- 359 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Polycomb protein eed
- UniProt
- O75530
- Ligands
- Q3A, NA
- Pockets
- 3 · best druggability 0.78
Structure
x-ray diffraction · 1 distinct chain · 6% helix, 47% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Polycomb protein eed | protein | 359 | 6% helix, 47% strand | O75530 |
Ligands and binding sites
- Q3A · 8-(2,6-dimethylpyridin-3-yl)-N-[(5-fluoro-2,3-dihydro-1-benzofuran-4-yl)methyl]-1-(methylsulfonyl)imidazo[1, 5-c]pyrimidin-5-amine · ligand · 3 copies · chains A
- NA · Sodium ion · metal · chains A
- FMT · Formic acid · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 458 | 0.78 | 0.86 | 44 | empty |
| 2 | 76 | 0.57 | 0.87 | 10 | Q3A |
| 3 | 80 | 0.37 | 0.76 | 14 | empty |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O75530
- Elsewhere: RCSB PDB 6W7G · PDBe 6W7G · UniProt O75530
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