MolNFT v1 · #168140 · protein

K106L/A131E mutant of cytochrome P460 from nitrosomonas sp. AL212

6W6N: “K106L/A131E mutant of cytochrome P460 from nitrosomonas sp. AL212”. X-ray diffraction, 1 ligand (HEC), 2 pockets (best druggability 0.74). MolNFT v1 #168140 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6W6N
Type: protein
Length: 318 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cytochrome P460
UniProt: F9ZFJ0
Ligands: HEC
Pockets: 2 · best druggability 0.74

Structure

x-ray diffraction · 2 distinct chains · 24% helix, 36% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cytochrome P460	protein	158	24% helix, 35% strand	F9ZFJ0
B	Cytochrome P460	protein	160	24% helix, 36% strand	F9ZFJ0

Ligands and binding sites

HEC · Heme C · ligand · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	251	0.74	0.88	37	HEC
2	211	0.72	0.88	39	HEC

Interfaces

1 interface between chains.

A–B · 1676 Å² buried · 20 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 cofactor (heme c attachment).

Compared structures

6W6N · K106L/A131E mutant of cytochrome P460 from Nitrosomonas sp. AL212 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt F9ZFJ0
Elsewhere: RCSB PDB 6W6N · PDBe 6W6N · UniProt F9ZFJ0

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