MolNFT v1 · #168120 · protein + RNA
Cryo-EM structure of CAS12I-crrna complex
6W62: “Cryo-EM structure of CAS12I-crrna complex”. Electron microscopy, 12 pockets (best druggability 0.73). MolNFT v1 #168120 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6W62
- Type
- protein + RNA
- Length
- 934 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- CAS12I; Crrna
- Pockets
- 12 · best druggability 0.73
Structure
electron microscopy · 2 distinct chains · 46% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | CAS12I | protein | 910 | 46% helix, 10% strand | — |
| B | Crrna | rna | 24 | — | — |
Pockets
12 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 807 | 0.73 | 0.78 | 66 | empty |
| 2 | 1139 | 0.72 | 0.76 | 89 | empty |
| 3 | 55 | 0.68 | 0.96 | 27 | empty |
| 4 | 56 | 0.66 | 0.94 | 15 | empty |
| 5 | 670 | 0.65 | 0.75 | 48 | empty |
Interfaces
1 interface between chains.
- A–B · 2343 Ų buried · 48 hydrogen bonds · protein-nucleic
Compared structures
- 6W62 · Cryo-EM structure of Cas12i-crRNA complex · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6W62 · PDBe 6W62
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