MolNFT v1 · #168082 · protein

Structure of anti-ferroportin FAB45D8

6W4V · FAB45D8 light chain: “Structure of anti-ferroportin FAB45D8”. X-ray diffraction, 6 pockets (best druggability 0.45). MolNFT v1 #168082 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6W4V
Type: protein
Length: 438 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: FAB45D8 light chain; FAB45D8 heavy chain
Pockets: 6 · best druggability 0.45

Structure

x-ray diffraction · 2 distinct chains · 5% helix, 52% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
D	FAB45D8 light chain	protein	218	6% helix, 52% strand	—
C	FAB45D8 heavy chain	protein	220	4% helix, 52% strand	—

Ligands and binding sites

EDO · 1,2-ethanediol · additive · 5 copies · chains D, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

6 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	204	0.45	0.74	26	empty
2	133	0.43	0.76	24	empty
3	83	0.41	0.78	17	empty
4	81	0.31	0.73	18	empty
5	50	0.31	0.77	13	empty

Interfaces

1 interface between chains.

D–C · 2047 Å² buried · 14 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 5 disulfide (disulfide).

Compared structures

6W4V · Structure of anti-ferroportin Fab45D8 · the same entry in another collection · chain D against D, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6W4V · PDBe 6W4V

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