MolNFT v1 · #168014 · protein
Mayaro virus glycoprotein E1 ectodomain and glycoportien E2 ectodomain asymmetric unit
6W2U · Spike glycoprotein E1: “Mayaro virus glycoprotein E1 ectodomain and glycoportien E2 ectodomain asymmetric unit”. Electron microscopy, 20 pockets (best druggability 0.74). MolNFT v1 #168014 on GenesisL1: 3D structure, binding sites…
- PDB
- 6W2U
- Type
- protein
- Length
- 2,880 residues
- Chains
- 8
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Spike glycoprotein E1; Spike glycoprotein E2
- UniProt
- Q8QZ72
- Pockets
- 20 · best druggability 0.74
Structure
electron microscopy · 2 distinct chains · 3% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Spike glycoprotein E1 | protein | 380 | 4% helix, 39% strand | Q8QZ72 |
| E, F, G, H | Spike glycoprotein E2 | protein | 340 | 1% helix, 37% strand | Q8QZ72 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 839 | 0.74 | 0.80 | 97 | empty |
| 2 | 1023 | 0.74 | 0.78 | 139 | empty |
| 3 | 1152 | 0.74 | 0.78 | 185 | empty |
| 4 | 1016 | 0.74 | 0.78 | 120 | empty |
| 5 | 1042 | 0.74 | 0.78 | 119 | empty |
Interfaces
11 interfaces between chains.
- D–H · 534 Ų buried · 17 hydrogen bonds · protein-protein
- A–E · 509 Ų buried · 16 hydrogen bonds · protein-protein
- B–F · 484 Ų buried · 11 hydrogen bonds · protein-protein
- C–G · 339 Ų buried · 5 hydrogen bonds · protein-protein
- C–D · 146 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 6W2U · Mayaro Virus glycoprotein E1 ectodomain and glycoportien E2 ectodomain asymmetric unit · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8QZ72
- Elsewhere: RCSB PDB 6W2U · PDBe 6W2U · UniProt Q8QZ72
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