MolNFT v1 · #167974 · protein
Human mabs broadly protect against infection of arthritiogenic alphaviruses by recognizing conserved elements of the MXR8 receptor binding domain
6W1C · E1 glycoprotein: “Human mabs broadly protect against infection of arthritiogenic alphaviruses by recognizing conserved elements…”. Electron microscopy, 20 pockets (best druggability 0.75). MolNFT v1 #167974 on GenesisL1: 3D…
- PDB
- 6W1C
- Type
- protein
- Length
- 4,596 residues
- Chains
- 16
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- E1 glycoprotein; E2 glycoprotein; Fab chk-265 heavy chain; Fab chk-265 light chain
- UniProt
- Q8QZ72
- Pockets
- 20 · best druggability 0.75
Structure
electron microscopy · 4 distinct chains · 3% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | E1 glycoprotein | protein | 380 | 3% helix, 33% strand | Q8QZ72 |
| E, F, G, H | E2 glycoprotein | protein | 340 | 3% helix, 32% strand | Q8QZ72 |
| I, J, K, L | Fab chk-265 heavy chain | protein | 218 | 1% helix, 45% strand | — |
| M, N, O, P | Fab chk-265 light chain | protein | 211 | 5% helix, 36% strand | — |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1151 | 0.75 | 0.79 | 178 | empty |
| 2 | 1049 | 0.75 | 0.78 | 166 | empty |
| 3 | 554 | 0.75 | 0.83 | 93 | empty |
| 4 | 843 | 0.74 | 0.79 | 93 | empty |
| 5 | 1113 | 0.74 | 0.78 | 122 | empty |
Interfaces
21 interfaces between chains.
- I–M · 604 Ų buried · 12 hydrogen bonds · protein-protein
- L–P · 563 Ų buried · 7 hydrogen bonds · protein-protein
- K–O · 541 Ų buried · 6 hydrogen bonds · protein-protein
- C–G · 534 Ų buried · 14 hydrogen bonds · protein-protein
- A–E · 530 Ų buried · 17 hydrogen bonds · protein-protein
Compared structures
- 6W1C · Human mAbs broadly protect against infection of arthritiogenic alphaviruses by… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8QZ72
- Elsewhere: RCSB PDB 6W1C · PDBe 6W1C · UniProt Q8QZ72
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.