MolNFT v1 · #167915 · protein

Crystal structure of human ppargamma ligand binding domain (protein delipidated by denature and refold)

6VZO · Peroxisome proliferator-activated receptor gamma: “Crystal structure of human ppargamma ligand binding domain (protein delipidated by denature and refold)”. X-ray diffraction, 9 pockets (best druggability 0.81). MolNFT v1 #167915 on…

PDB: 6VZO
Type: protein
Length: 514 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Peroxisome proliferator-activated receptor gamma
UniProt: P37231
Pockets: 9 · best druggability 0.81

Structure

x-ray diffraction · 2 distinct chains · 66% helix, 5% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Peroxisome proliferator-activated receptor gamma	protein	260	64% helix, 5% strand	P37231
B	Peroxisome proliferator-activated receptor gamma	protein	254	68% helix, 5% strand	P37231

Pockets

9 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	415	0.81	0.89	52	empty
2	384	0.73	0.84	50	empty
3	506	0.68	0.78	41	empty
4	202	0.57	0.79	24	empty
5	114	0.51	0.82	16	empty

Interfaces

1 interface between chains.

A–B · 914 Å² buried · 8 hydrogen bonds · protein-protein

Compared structures

6VZO · Crystal structure of human PPARgamma ligand binding domain (Protein delipidated by… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P37231
Elsewhere: RCSB PDB 6VZO · PDBe 6VZO · UniProt P37231

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