MolNFT v1 · #167805 · protein
W0 fused 4-ot wild type symmetric trimer
6VVW · Tautomerase: “W0 fused 4-ot wild type symmetric trimer”. X-ray diffraction, 12 pockets (best druggability 0.57). MolNFT v1 #167805 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6VVW
- Type
- protein
- Length
- 964 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tautomerase
- EC
- 5.3.2.-
- UniProt
- W0PD56
- Pockets
- 12 · best druggability 0.57
Structure
x-ray diffraction · 3 distinct chains · 31% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, E, G | Tautomerase (EC 5.3.2.-) | protein | 121 | 33% helix, 28% strand | W0PD56 |
| B, F | Tautomerase (EC 5.3.2.-) | protein | 118 | 25% helix, 27% strand | W0PD56 |
| D, H | Tautomerase (EC 5.3.2.-) | protein | 122 | 34% helix, 30% strand | W0PD56 |
Pockets
12 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 442 | 0.57 | 0.74 | 45 | empty |
| 2 | 210 | 0.48 | 0.75 | 23 | empty |
| 3 | 153 | 0.45 | 0.76 | 20 | empty |
| 4 | 165 | 0.44 | 0.75 | 22 | empty |
| 5 | 150 | 0.41 | 0.74 | 25 | empty |
Interfaces
8 interfaces between chains.
- B–D · 354 Ų buried · 6 hydrogen bonds · protein-protein
- F–H · 335 Ų buried · 9 hydrogen bonds · protein-protein
- B–C · 203 Ų buried · 4 hydrogen bonds · protein-protein
- A–D · 186 Ų buried · 2 hydrogen bonds · protein-protein
- E–H · 171 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 6VVW · W0 fused 4-OT wild type symmetric trimer · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt W0PD56
- Elsewhere: RCSB PDB 6VVW · PDBe 6VVW · UniProt W0PD56
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