MolNFT v1 · #167721 · protein

P53-specific T cell receptor

6VTC · T-cell receptor 1A2: “P53-specific T cell receptor”. X-ray diffraction, 5 pockets (best druggability 0.70). MolNFT v1 #167721 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6VTC
Type: protein
Length: 440 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: T-cell receptor 1A2; P53-specific T cell receptor, B-chain
Pockets: 5 · best druggability 0.70

Structure

x-ray diffraction · 2 distinct chains · 6% helix, 47% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	T-cell receptor 1A2	protein	197	5% helix, 44% strand	—
B	P53-specific T cell receptor, B-chain	protein	243	6% helix, 50% strand	—

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	913	0.70	0.75	68	empty
2	104	0.39	0.76	24	empty
3	91	0.39	0.76	16	empty
4	68	0.33	0.75	14	empty
5	51	0.31	0.77	17	empty

Interfaces

1 interface between chains.

A–B · 2045 Å² buried · 25 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 5 disulfide (disulfide).

Compared structures

6VTC · p53-specific T cell receptor · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6VTC · PDBe 6VTC

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