MolNFT v1 · #167632 · protein
Cryoem structure of the plasmodium falciparum transporter pffnt
6VQQ · Formate-nitrite transporter: “Cryoem structure of the plasmodium falciparum transporter pffnt”. Electron microscopy, 18 pockets (best druggability 0.87). MolNFT v1 #167632 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 6VQQ
- Type
- protein
- Length
- 1,399 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Formate-nitrite transporter
- UniProt
- O77389
- Pockets
- 18 · best druggability 0.87
Structure
electron microscopy · 5 distinct chains · 75% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Formate-nitrite transporter | protein | 279 | 75% helix, 1% strand | O77389 |
| B | Formate-nitrite transporter | protein | 282 | 77% helix, 0% strand | O77389 |
| C | Formate-nitrite transporter | protein | 278 | 74% helix, 0% strand | O77389 |
| D | Formate-nitrite transporter | protein | 283 | 73% helix, 0% strand | O77389 |
| E | Formate-nitrite transporter | protein | 277 | 76% helix, 1% strand | O77389 |
Pockets
18 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 959 | 0.87 | 0.87 | 64 | empty |
| 2 | 671 | 0.79 | 0.83 | 55 | empty |
| 3 | 604 | 0.79 | 0.84 | 57 | empty |
| 4 | 580 | 0.78 | 0.84 | 55 | empty |
| 5 | 495 | 0.78 | 0.85 | 51 | empty |
Interfaces
8 interfaces between chains.
- A–D · 2031 Ų buried · 9 hydrogen bonds · protein-protein
- A–B · 2015 Ų buried · 10 hydrogen bonds · protein-protein
- B–E · 1955 Ų buried · 12 hydrogen bonds · protein-protein
- C–D · 1918 Ų buried · 7 hydrogen bonds · protein-protein
- C–E · 1803 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 6VQQ · CryoEM Structure of the Plasmodium falciparum transporter PfFNT · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O77389
- Elsewhere: RCSB PDB 6VQQ · PDBe 6VQQ · UniProt O77389
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