MolNFT v1 · #167627 · protein
Crystal structure of interleukin-1 receptor-associated kinase 4 (IRAK4-wt) complex with a nicotinamide inhibitor
6VQL: “Crystal structure of interleukin-1 receptor-associated kinase 4 (IRAK4-wt) complex with a nicotinamide…”. X-ray diffraction, 2 ligands (R7S, SO4). MolNFT v1 #167627 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6VQL
- Type
- protein
- Length
- 1,149 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q9NWZ3
- Ligands
- R7S, SO4
Structure
x-ray diffraction · 4 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 289 | — | Q9NWZ3 |
| B | — | protein | 286 | — | Q9NWZ3 |
| C | — | protein | 287 | — | Q9NWZ3 |
| D | — | protein | 287 | — | Q9NWZ3 |
Ligands and binding sites
- R7S · 6-[(1,3-benzothiazol-6-yl)amino]-4-(cyclopropylamino)-N-[(2R)-2-fluoro-3-hydroxy-3-methylbutyl]pyridine-3-carboxamide · ligand · 4 copies · chains A, B, C, D
- SO4 · Sulfate ion · ion · 10 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6VQL · Crystal structure of interleukin-1 receptor-associated kinase 4 (IRAK4-wt) complex with a… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NWZ3
- Elsewhere: RCSB PDB 6VQL · PDBe 6VQL · UniProt Q9NWZ3
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