MolNFT v1 · #167518 · protein
JAK2 JH1 in complex with fedratinib
6VNE: “JAK2 JH1 in complex with fedratinib”. X-ray diffraction, 1 ligand (2TA). MolNFT v1 #167518 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6VNE
- Type
- protein
- Length
- 581 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- O60674
- Ligands
- 2TA
Structure
x-ray diffraction · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | — | protein | 289 | — | O60674 |
| A | — | protein | 292 | — | O60674 |
Ligands and binding sites
- 2TA · N-tert-butyl-3-{[5-methyl-2-({4-[2-(pyrrolidin-1-yl) ethoxy]phenyl}amino)pyrimidin-4-yl]amino}benzenesulfonamide · ligand · 2 copies · chains B, A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6VNE · JAK2 JH1 in complex with Fedratinib · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O60674
- Elsewhere: RCSB PDB 6VNE · PDBe 6VNE · UniProt O60674
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