MolNFT v1 · #167492 · protein

Human escrt-I heterotetramer headpiece

6VME · Tumor susceptibility gene 101 protein: “Human escrt-I heterotetramer headpiece”. X-ray diffraction, 15 pockets (best druggability 0.81). MolNFT v1 #167492 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6VME
Type: protein
Length: 1,576 residues
Chains: 24
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tumor susceptibility gene 101 protein; Vacuolar protein sorting-associated protein 37B…
UniProt: Q99816, Q9H9H4, Q96EY5, Q9UK41
Pockets: 15 · best druggability 0.81

Structure

x-ray diffraction · 21 distinct chains · 70% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	Tumor susceptibility gene 101 protein	protein	76	78% helix, 4% strand	Q99816
C, N	Vacuolar protein sorting-associated protein 37B	protein	67	82% helix, 0% strand	Q9H9H4
D	Multivesicular body subunit 12A	protein	19	37% helix, 16% strand	Q96EY5
E	Vacuolar protein sorting-associated protein 28 homolog	protein	102	65% helix, 0% strand	Q9UK41
F	Tumor susceptibility gene 101 protein	protein	77	79% helix, 4% strand	Q99816
G	Tumor susceptibility gene 101 protein	protein	75	75% helix, 4% strand	Q99816
H, J	Tumor susceptibility gene 101 protein	protein	76	79% helix, 4% strand	Q99816
I	Tumor susceptibility gene 101 protein	protein	75	76% helix, 4% strand	Q99816
K, L	Vacuolar protein sorting-associated protein 37B	protein	65	85% helix, 0% strand	Q9H9H4
M	Vacuolar protein sorting-associated protein 37B	protein	65	88% helix, 0% strand	Q9H9H4
O	Vacuolar protein sorting-associated protein 37B	protein	62	85% helix, 0% strand	Q9H9H4
P	Multivesicular body subunit 12A	protein	20	35% helix, 15% strand	Q96EY5
Q	Multivesicular body subunit 12A	protein	18	22% helix, 17% strand	Q96EY5
R	Multivesicular body subunit 12A	protein	21	33% helix, 14% strand	Q96EY5
A	Multivesicular body subunit 12A	protein	20	35% helix, 15% strand	Q96EY5
T	Multivesicular body subunit 12A	protein	18	39% helix, 11% strand	Q96EY5
U	Vacuolar protein sorting-associated protein 28 homolog	protein	102	65% helix, 0% strand	Q9UK41
V	Vacuolar protein sorting-associated protein 28 homolog	protein	104	67% helix, 0% strand	Q9UK41
W	Vacuolar protein sorting-associated protein 28 homolog	protein	105	67% helix, 0% strand	Q9UK41
X	Vacuolar protein sorting-associated protein 28 homolog	protein	101	68% helix, 0% strand	Q9UK41
Y	Vacuolar protein sorting-associated protein 28 homolog	protein	100	66% helix, 0% strand	Q9UK41

Pockets

15 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	724	0.81	0.85	71	empty
2	356	0.76	0.87	41	empty
3	442	0.75	0.84	43	empty
4	689	0.69	0.77	68	empty
5	551	0.63	0.75	58	empty

Interfaces

51 interfaces between chains.

F–U · 1570 Å² buried · 19 hydrogen bonds · protein-protein
G–V · 1553 Å² buried · 17 hydrogen bonds · protein-protein
B–E · 1533 Å² buried · 19 hydrogen bonds · protein-protein
I–X · 1512 Å² buried · 16 hydrogen bonds · protein-protein
H–W · 1465 Å² buried · 15 hydrogen bonds · protein-protein

Compared structures

6VME · Human ESCRT-I heterotetramer headpiece · the same entry in another collection · chain L against L, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q99816
Every structure of UniProt Q9H9H4
Every structure of UniProt Q96EY5
Every structure of UniProt Q9UK41
Elsewhere: RCSB PDB 6VME · PDBe 6VME · UniProt Q99816 · UniProt Q9H9H4 · UniProt Q96EY5 · UniProt Q9UK41

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.