MolNFT v1 · #167458 · protein
Crystal structure of mouse alpha 1,6-fucosyltransferase, FUT8 in its apo-form
6VLF · Alpha-(1,6)-fucosyltransferase: “Crystal structure of mouse alpha 1,6-fucosyltransferase, FUT8 in its apo-form”. X-ray diffraction, 1 ligand (SO4), 14 pockets (best druggability 0.85). MolNFT v1 #167458 on GenesisL1: 3D structure…
- PDB
- 6VLF
- Type
- protein
- Length
- 898 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Alpha-(1,6)-fucosyltransferase
- EC
- 2.4.1.68
- UniProt
- Q9WTS2
- Ligands
- SO4
- Pockets
- 14 · best druggability 0.85
Structure
x-ray diffraction · 2 distinct chains · 45% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) | protein | 447 | 46% helix, 17% strand | Q9WTS2 |
| B | Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) | protein | 451 | 44% helix, 16% strand | Q9WTS2 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 4 copies · chains A, B
- EDO · 1,2-ethanediol · additive · 9 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
14 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1177 | 0.85 | 0.85 | 96 | empty |
| 2 | 1160 | 0.84 | 0.85 | 96 | empty |
| 3 | 213 | 0.56 | 0.79 | 29 | empty |
| 4 | 147 | 0.54 | 0.80 | 21 | EDO |
| 5 | 145 | 0.53 | 0.80 | 24 | empty |
Interfaces
1 interface between chains.
- A–B · 3435 Ų buried · 29 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 6VLF · Crystal structure of mouse alpha 1,6-fucosyltransferase, FUT8 in its Apo-form · the same entry in another collection · chain A against A, TM-score 1.00
- Q9WTS2 · AlphaFold monomer V2.0 prediction for alpha-(1,6)-fucosyltransferase (Q9WTS2) · a predicted model of the same protein · chain B against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9WTS2
- Elsewhere: RCSB PDB 6VLF · PDBe 6VLF · UniProt Q9WTS2
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