MolNFT v1 · #16739 · protein

Crystal structure of ip-10 T-form

1O7Z · Small inducible cytokine B10: “Crystal structure of ip-10 T-form”. X-ray diffraction, 1 pocket (best druggability 0.51). MolNFT v1 #16739 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1O7Z
Type: protein
Length: 115 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Small inducible cytokine B10
UniProt: P02778
Pockets: 1 · best druggability 0.51

Structure

x-ray diffraction · 2 distinct chains · 11% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Small inducible cytokine B10	protein	60	15% helix, 30% strand	P02778
B	Small inducible cytokine B10	protein	55	7% helix, 33% strand	P02778

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	206	0.51	0.76	26	empty

Interfaces

1 interface between chains.

A–B · 498 Å² buried · 6 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

1O7Z · Crystal structure of IP-10 T-form · the same entry in another collection · chain A against A, TM-score 1.00
P02778 · AlphaFold monomer V2.0 prediction for C-X-C motif chemokine 10 (P02778) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P02778
Elsewhere: RCSB PDB 1O7Z · PDBe 1O7Z · UniProt P02778

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