MolNFT v1 · #16737 · protein
Citrate synthase from sulfolobus solfataricus
1O7X: “Citrate synthase from sulfolobus solfataricus”. X-ray diffraction, 12 pockets (best druggability 0.75). MolNFT v1 #16737 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1O7X
- Type
- protein
- Length
- 1,468 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Citrate synthase
- EC
- 4.1.3.7
- UniProt
- P80148
- Pockets
- 12 · best druggability 0.75
Structure
x-ray diffraction · 4 distinct chains · 60% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Citrate synthase (EC 4.1.3.7) | protein | 367 | 60% helix, 6% strand | P80148 |
| B | Citrate synthase (EC 4.1.3.7) | protein | 366 | 62% helix, 6% strand | P80148 |
| C | Citrate synthase (EC 4.1.3.7) | protein | 370 | 60% helix, 6% strand | P80148 |
| D | Citrate synthase (EC 4.1.3.7) | protein | 365 | 59% helix, 6% strand | P80148 |
Pockets
12 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 598 | 0.75 | 0.82 | 53 | empty |
| 2 | 373 | 0.73 | 0.85 | 38 | empty |
| 3 | 561 | 0.72 | 0.80 | 53 | empty |
| 4 | 391 | 0.72 | 0.83 | 41 | empty |
| 5 | 187 | 0.54 | 0.79 | 20 | empty |
Interfaces
3 interfaces between chains.
- C–D · 3858 Ų buried · 47 hydrogen bonds · protein-protein
- A–B · 3727 Ų buried · 43 hydrogen bonds · protein-protein
- A–D · 10 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P80148
- Elsewhere: RCSB PDB 1O7X · PDBe 1O7X · UniProt P80148
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