MolNFT v1 · #167302 · protein
JAK2 JH1 in complex with ruxolitinib
6VGL: “JAK2 JH1 in complex with ruxolitinib”. X-ray diffraction, 1 ligand (RXT). MolNFT v1 #167302 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6VGL
- Type
- protein
- Length
- 1,181 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- O60674
- Ligands
- RXT
Structure
x-ray diffraction · 3 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| D, C | — | protein | 289 | — | O60674 |
| B | — | protein | 298 | — | O60674 |
| A | — | protein | 305 | — | O60674 |
Ligands and binding sites
- RXT · (3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile · ligand · 4 copies · chains D, B, A, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6VGL · JAK2 JH1 in complex with ruxolitinib · the same entry in another collection · chain D against D, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O60674
- Elsewhere: RCSB PDB 6VGL · PDBe 6VGL · UniProt O60674
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