MolNFT v1 · #16720 · protein
Crystal structure of the regulatory domain of EPAC2
1O7F · Camp-dependent RAP1 guanine-nucleotide exchange factor: “Crystal structure of the regulatory domain of EPAC2”. X-ray diffraction, 6 pockets (best druggability 0.65). MolNFT v1 #16720 on GenesisL1: 3D structure, binding sites and…
- PDB
- 1O7F
- Type
- protein
- Length
- 421 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Camp-dependent RAP1 guanine-nucleotide exchange factor
- UniProt
- Q9Z1P0
- Pockets
- 6 · best druggability 0.65
Structure
x-ray diffraction · 1 distinct chain · 38% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Camp-dependent RAP1 guanine-nucleotide exchange factor | protein | 421 | 38% helix, 24% strand | Q9Z1P0 |
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 77 | 0.65 | 0.92 | 23 | empty |
| 2 | 58 | 0.64 | 0.93 | 17 | empty |
| 3 | 128 | 0.50 | 0.80 | 17 | empty |
| 4 | 150 | 0.45 | 0.76 | 28 | empty |
| 5 | 86 | 0.34 | 0.74 | 16 | empty |
Compared structures
- 1O7F · Crystal structure of the regulatory domain of EPAC2 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Z1P0
- Elsewhere: RCSB PDB 1O7F · PDBe 1O7F · UniProt Q9Z1P0
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