MolNFT v1 · #167097 · protein

Cryo-EM structure of octameric chicken CALHM1

6VAM · Green fluorescent PROTEIN,CALHM1 chimera: “Cryo-EM structure of octameric chicken CALHM1”. Electron microscopy, 20 pockets (best druggability 0.75). MolNFT v1 #167097 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6VAM
Type: protein
Length: 1,712 residues
Chains: 8
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Green fluorescent PROTEIN,CALHM1 chimera
UniProt: P42212, A0A1D5NWS1
Pockets: 20 · best druggability 0.75

Structure

electron microscopy · 1 distinct chain · 71% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F, G, H	Green fluorescent PROTEIN,CALHM1 chimera	protein	214	71% helix, 0% strand	P42212, A0A1D5NWS1

Pockets

20 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	855	0.75	0.79	74	empty
2	883	0.75	0.78	85	empty
3	818	0.74	0.78	76	empty
4	1200	0.74	0.77	93	empty
5	1104	0.74	0.77	82	empty

Interfaces

16 interfaces between chains.

A–H · 1844 Å² buried · 12 hydrogen bonds · protein-protein
C–D · 1841 Å² buried · 12 hydrogen bonds · protein-protein
F–G · 1836 Å² buried · 12 hydrogen bonds · protein-protein
A–B · 1833 Å² buried · 12 hydrogen bonds · protein-protein
B–C · 1833 Å² buried · 12 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 8 disulfide (disulfide).

Compared structures

6VAM · Cryo-EM structure of octameric chicken CALHM1 · the same entry in another collection · chain H against H, TM-score 1.00
P42212 · AlphaFold monomer V2.0 prediction for green fluorescent protein (P42212) · a predicted model of the same protein · chain G against A, TM-score 0.26

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P42212
Every structure of UniProt A0A1D5NWS1
Elsewhere: RCSB PDB 6VAM · PDBe 6VAM · UniProt P42212 · UniProt A0A1D5NWS1

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.