MolNFT v1 · #16706 · protein
Novel fold revealed by the structure of a FAS1 domain pair from the insect cell adhesion molecule fasciclin I
1O70: “Novel fold revealed by the structure of a FAS1 domain pair from the insect cell adhesion molecule fasciclin I”. X-ray diffraction, 2 ligands (NAG, SO4), 2 pockets (best druggability 0.61). MolNFT v1 #16706 on GenesisL1: 3D…
- PDB
- 1O70
- Type
- protein
- Length
- 296 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fasciclin I
- UniProt
- P10674
- Ligands
- NAG, SO4
- Pockets
- 2 · best druggability 0.61
Structure
x-ray diffraction · 1 distinct chain · 37% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fasciclin I | protein | 296 | 37% helix, 30% strand | P10674 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains A
- SO4 · Sulfate ion · ion · 4 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 310 | 0.61 | 0.79 | 44 | empty |
| 2 | 97 | 0.40 | 0.77 | 19 | NAG, SO4 |
Modifications
Observed in the structure: 1 glycan (N-glycosylation).
Compared structures
- 1O70 · Novel Fold Revealed by the Structure of a FAS1 Domain Pair from the Insect Cell Adhesion… · the same entry in another collection · chain A against A, TM-score 1.00
- P10674 · AlphaFold monomer V2.0 prediction for fasciclin-1 (P10674) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10674
- Elsewhere: RCSB PDB 1O70 · PDBe 1O70 · UniProt P10674
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