MolNFT v1 · #167058 · protein

Kindlin-3 double deletion mutant long form

6V9G · Fermitin family homolog 3: “Kindlin-3 double deletion mutant long form”. X-ray diffraction, 10 pockets (best druggability 0.80). MolNFT v1 #167058 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6V9G
Type: protein
Length: 823 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fermitin family homolog 3
UniProt: Q86UX7
Pockets: 10 · best druggability 0.80

Structure

x-ray diffraction · 2 distinct chains · 34% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Fermitin family homolog 3	protein	412	35% helix, 23% strand	Q86UX7
B	Fermitin family homolog 3	protein	411	33% helix, 23% strand	Q86UX7

Pockets

10 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1178	0.80	0.82	111	empty
2	359	0.69	0.82	42	empty
3	54	0.64	0.94	17	empty
4	141	0.46	0.77	25	empty
5	134	0.45	0.77	25	empty

Interfaces

1 interface between chains.

A–B · 710 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

6V9G · Kindlin-3 double deletion mutant long form · the same entry in another collection · chain A against A, TM-score 1.00
Q86UX7 · AlphaFold monomer V2.0 prediction for fermitin family homolog 3 (Q86UX7) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q86UX7
Elsewhere: RCSB PDB 6V9G · PDBe 6V9G · UniProt Q86UX7

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