MolNFT v1 · #166949 · protein
Structures of GCP4 and GCP5 in the native human gamma-tubulin ring complex
6V69 · Gamma-tubulin complex component 5: “Structures of GCP4 and GCP5 in the native human gamma-tubulin ring complex”. Electron microscopy, 17 pockets (best druggability 0.74). MolNFT v1 #166949 on GenesisL1: 3D structure, binding sites…
- PDB
- 6V69
- Type
- protein
- Length
- 1,027 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Gamma-tubulin complex component 5; Gamma-tubulin complex component 4
- UniProt
- Q96RT8, Q9UGJ1
- Pockets
- 17 · best druggability 0.74
Structure
electron microscopy · 2 distinct chains · 67% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| J | Gamma-tubulin complex component 5 | protein | 484 | 67% helix, 0% strand | Q96RT8 |
| I | Gamma-tubulin complex component 4 | protein | 543 | 66% helix, 3% strand | Q9UGJ1 |
Pockets
17 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 867 | 0.74 | 0.78 | 81 | empty |
| 2 | 70 | 0.72 | 0.96 | 18 | empty |
| 3 | 56 | 0.70 | 0.96 | 17 | empty |
| 4 | 256 | 0.69 | 0.84 | 39 | empty |
| 5 | 71 | 0.63 | 0.90 | 16 | empty |
Interfaces
1 interface between chains.
- J–I · 966 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 6V69 · Structures of GCP4 and GCP5 in the native human gamma-tubulin ring complex · the same entry in another collection · chain J against J, TM-score 1.00
- Q96RT8 · AlphaFold monomer V2.0 prediction for gamma-tubulin complex component 5 (Q96RT8) · a predicted model of the same protein · chain J against A, TM-score 0.97
- Q9UGJ1 · AlphaFold monomer V2.0 prediction for gamma-tubulin complex component 4 (Q9UGJ1) · a predicted model of the same protein · chain I against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q96RT8
- Every structure of UniProt Q9UGJ1
- Elsewhere: RCSB PDB 6V69 · PDBe 6V69 · UniProt Q96RT8 · UniProt Q9UGJ1
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