MolNFT v1 · #166843 · protein

Crystal structure of clc-EC1 triple mutant (E113Q, E148Q, E203Q)

6V2J · H(+)/CL(-) exchange transporter clca: “Crystal structure of clc-EC1 triple mutant (E113Q, E148Q, E203Q)”. X-ray diffraction, 1 ligand (CL), 2 pockets (best druggability 0.68). MolNFT v1 #166843 on GenesisL1: 3D structure, binding…

PDB: 6V2J
Type: protein
Length: 435 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: H(+)/CL(-) exchange transporter clca
UniProt: P37019
Ligands: CL
Pockets: 2 · best druggability 0.68

Structure

x-ray diffraction · 1 distinct chain · 77% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	H(+)/CL(-) exchange transporter clca	protein	435	77% helix, 1% strand	P37019

Ligands and binding sites

CL · Chloride ion · ion · 3 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	373	0.68	0.81	30	CL
2	309	0.61	0.79	45	empty

Compared structures

6V2J · Crystal structure of ClC-ec1 triple mutant (E113Q, E148Q, E203Q) · the same entry in another collection · chain A against A, TM-score 1.00
P37019 · AlphaFold monomer V2.0 prediction for H(+)/CL(-) exchange transporter clca (P37019) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P37019
Elsewhere: RCSB PDB 6V2J · PDBe 6V2J · UniProt P37019

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