MolNFT v1 · #166788 · protein
Crystal structure of catalytic subunit of bovine pyruvate dehydrogenase phosphatase 1 - catalytic domain
6V0T · [pyruvate dehydrogenase [acetyl-transferring]]-phosphatase…: “Crystal structure of catalytic subunit of bovine pyruvate dehydrogenase phosphatase 1 - catalytic domain”. X-ray diffraction, 2 ligands (MN, SO4), 4 pockets (best…
- PDB
- 6V0T
- Type
- protein
- Length
- 402 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- [pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial
- EC
- 3.1.3.43
- UniProt
- P35816
- Ligands
- MN, SO4
- Pockets
- 4 · best druggability 0.54
Structure
x-ray diffraction · 1 distinct chain · 40% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | [pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial (EC 3.1.3.43) | protein | 402 | 40% helix, 23% strand | P35816 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 161 | 0.54 | 0.80 | 21 | empty |
| 2 | 87 | 0.36 | 0.75 | 19 | empty |
| 3 | 93 | 0.35 | 0.75 | 18 | MN |
| 4 | 75 | 0.32 | 0.75 | 18 | empty |
Compared structures
- 6V0T · Crystal Structure of Catalytic Subunit of Bovine Pyruvate Dehydrogenase Phosphatase 1… · the same entry in another collection · chain A against A, TM-score 1.00
- P35816 · AlphaFold monomer V2.0 prediction for [pyruvate dehydrogenase… · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P35816
- Elsewhere: RCSB PDB 6V0T · PDBe 6V0T · UniProt P35816
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