MolNFT v1 · #166776 · protein
Lipophilic envelope-spanning tunnel B (letb), model 6
6V0H · Intermembrane transport protein yebt: “Lipophilic envelope-spanning tunnel B (letb), model 6”. Electron microscopy, 20 pockets (best druggability 0.81). MolNFT v1 #166776 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6V0H
- Type
- protein
- Length
- 2,178 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Intermembrane transport protein yebt
- UniProt
- P76272
- Pockets
- 20 · best druggability 0.81
Structure
electron microscopy · 1 distinct chain · 10% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F | Intermembrane transport protein yebt | protein | 363 | 10% helix, 34% strand | P76272 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 878 | 0.81 | 0.83 | 103 | empty |
| 2 | 808 | 0.80 | 0.83 | 98 | empty |
| 3 | 1169 | 0.80 | 0.81 | 101 | empty |
| 4 | 739 | 0.79 | 0.83 | 92 | empty |
| 5 | 464 | 0.74 | 0.83 | 57 | empty |
Interfaces
6 interfaces between chains.
- A–B · 2097 Ų buried · 17 hydrogen bonds · protein-protein
- A–F · 2075 Ų buried · 16 hydrogen bonds · protein-protein
- B–C · 2074 Ų buried · 18 hydrogen bonds · protein-protein
- C–D · 2069 Ų buried · 17 hydrogen bonds · protein-protein
- D–E · 2064 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- 6V0H · Lipophilic Envelope-spanning Tunnel B (LetB), Model 6 · the same entry in another collection · chain C against C, TM-score 1.00
- P76272 · AlphaFold monomer V2.0 prediction for intermembrane transport protein yebt (P76272) · a predicted model of the same protein · chain A against A, TM-score 0.90
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P76272
- Elsewhere: RCSB PDB 6V0H · PDBe 6V0H · UniProt P76272
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