MolNFT v1 · #166753 · protein
Crystal structure of rptp alpha
6UZT · Receptor-type tyrosine-protein phosphatase alpha: “Crystal structure of rptp alpha”. X-ray diffraction, 15 pockets (best druggability 0.77). MolNFT v1 #166753 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6UZT
- Type
- protein
- Length
- 1,159 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Receptor-type tyrosine-protein phosphatase alpha
- EC
- 3.1.3.48
- UniProt
- P18433
- Pockets
- 15 · best druggability 0.77
Structure
x-ray diffraction · 2 distinct chains · 36% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Receptor-type tyrosine-protein phosphatase alpha (EC 3.1.3.48) | protein | 587 | 37% helix, 22% strand | P18433 |
| B | Receptor-type tyrosine-protein phosphatase alpha (EC 3.1.3.48) | protein | 572 | 36% helix, 23% strand | P18433 |
Pockets
15 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 792 | 0.77 | 0.81 | 77 | empty |
| 2 | 654 | 0.75 | 0.81 | 71 | empty |
| 3 | 455 | 0.61 | 0.76 | 51 | empty |
| 4 | 138 | 0.55 | 0.82 | 23 | empty |
| 5 | 143 | 0.53 | 0.80 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 419 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P18433
- Elsewhere: RCSB PDB 6UZT · PDBe 6UZT · UniProt P18433
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