MolNFT v1 · #166613 · protein
Structure of antibody 3G12 bound to the central conserved domain of rsv G
6UVO · 3G12 Fab light chain: “Structure of antibody 3G12 bound to the central conserved domain of rsv G”. X-ray diffraction, 5 pockets (best druggability 0.59). MolNFT v1 #166613 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 6UVO
- Type
- protein
- Length
- 471 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 3G12 Fab light chain; 3G12 Fab heavy chain; Major surface glycoprotein G
- UniProt
- P03423
- Pockets
- 5 · best druggability 0.59
Structure
x-ray diffraction · 3 distinct chains · 9% helix, 49% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | 3G12 Fab light chain | protein | 212 | 6% helix, 51% strand | — |
| H | 3G12 Fab heavy chain | protein | 229 | 8% helix, 52% strand | — |
| D | Major surface glycoprotein G | protein | 30 | 30% helix, 10% strand | P03423 |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 507 | 0.59 | 0.73 | 58 | empty |
| 2 | 59 | 0.47 | 0.84 | 18 | empty |
| 3 | 63 | 0.45 | 0.83 | 23 | empty |
| 4 | 70 | 0.31 | 0.74 | 19 | empty |
| 5 | 55 | 0.28 | 0.74 | 17 | empty |
Interfaces
3 interfaces between chains.
- L–H · 2160 Ų buried · 13 hydrogen bonds · protein-protein
- H–D · 715 Ų buried · 12 hydrogen bonds · protein-protein
- L–D · 244 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 6UVO · Structure of antibody 3G12 bound to the central conserved domain of RSV G · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03423
- Elsewhere: RCSB PDB 6UVO · PDBe 6UVO · UniProt P03423
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