MolNFT v1 · #16648 · protein
Crystal structure of O-acetylserine sulfhydrylase (TM0665) from thermotoga maritima at 1.80 a resolution
1O58: “Crystal structure of O-acetylserine sulfhydrylase (TM0665) from thermotoga maritima at 1.80 a resolution”. X-ray diffraction, 1 ligand (PO4), 12 pockets (best druggability 0.74). MolNFT v1 #16648 on GenesisL1: 3D structure, binding…
- PDB
- 1O58
- Type
- protein
- Length
- 1,123 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- O-acetylserine sulfhydrylase
- EC
- 2.5.1.47
- UniProt
- Q9WZD3
- Ligands
- PO4
- Pockets
- 12 · best druggability 0.74
Structure
x-ray diffraction · 4 distinct chains · 44% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | O-acetylserine sulfhydrylase (EC 2.5.1.47) | protein | 293 | 45% helix, 17% strand | Q9WZD3 |
| B | O-acetylserine sulfhydrylase (EC 2.5.1.47) | protein | 285 | 44% helix, 17% strand | Q9WZD3 |
| C | O-acetylserine sulfhydrylase (EC 2.5.1.47) | protein | 266 | 44% helix, 16% strand | Q9WZD3 |
| D | O-acetylserine sulfhydrylase (EC 2.5.1.47) | protein | 279 | 43% helix, 16% strand | Q9WZD3 |
Ligands and binding sites
- PO4 · Phosphate ion · ion · 8 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
12 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 704 | 0.74 | 0.80 | 74 | empty |
| 2 | 63 | 0.72 | 0.98 | 26 | PO4 |
| 3 | 224 | 0.71 | 0.87 | 48 | PO4 |
| 4 | 423 | 0.68 | 0.80 | 49 | empty |
| 5 | 188 | 0.65 | 0.85 | 47 | PO4 |
Interfaces
5 interfaces between chains.
- A–B · 1565 Ų buried · 20 hydrogen bonds · protein-protein
- C–D · 1538 Ų buried · 19 hydrogen bonds · protein-protein
- B–D · 1159 Ų buried · 19 hydrogen bonds · protein-protein
- A–C · 1135 Ų buried · 18 hydrogen bonds · protein-protein
- A–D · 11 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 1O58 · Crystal structure of O-acetylserine sulfhydrylase (TM0665) from Thermotoga maritima at… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9WZD3
- Elsewhere: RCSB PDB 1O58 · PDBe 1O58 · UniProt Q9WZD3
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.