MolNFT v1 · #1664 · protein

Brain derived neurotrophic factor, neurotrophin-4

1B8M · Protein (brain derived neurotrophic factor): “Brain derived neurotrophic factor, neurotrophin-4”. X-ray diffraction, 2 pockets (best druggability 0.75). MolNFT v1 #1664 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1B8M
Type: protein
Length: 224 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein (brain derived neurotrophic factor); Protein (neurotrophin-4)
Pockets: 2 · best druggability 0.75

Structure

x-ray diffraction · 2 distinct chains · 2% helix, 57% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein (brain derived neurotrophic factor)	protein	109	4% helix, 60% strand	—
B	Protein (neurotrophin-4)	protein	115	0% helix, 54% strand	—

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	176	0.75	0.91	36	empty
2	96	0.45	0.80	28	empty

Interfaces

1 interface between chains.

A–B · 1485 Å² buried · 12 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 disulfide (disulfide).

Compared structures

1B8M · Brain derived neurotrophic factor, neurotrophin-4 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 1B8M · PDBe 1B8M

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