MolNFT v1 · #166198 · protein
DYRK1A kinase domain in complex with a 6-azaindole derivative, GNF2133.
6UIP: “DYRK1A kinase domain in complex with a 6-azaindole derivative, GNF2133.”. X-ray diffraction, 1 ligand (Q8J). MolNFT v1 #166198 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6UIP
- Type
- protein
- Length
- 989 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q13627
- Ligands
- Q8J
Structure
x-ray diffraction · 3 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 345 | — | Q13627 |
| B | — | protein | 338 | — | Q13627 |
| C | — | protein | 306 | — | Q13627 |
Ligands and binding sites
- Q8J · 4-ethyl-N-{4-[1-(oxan-4-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]pyridin-2-yl}piperazine-1-carboxamide · ligand · 3 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6UIP · DYRK1A Kinase Domain in Complex with a 6-azaindole Derivative, GNF2133. · the same entry in another collection · chain A against A, TM-score 1.00
- Q13627 · AlphaFold monomer V2.0 prediction for dual specificity tyrosine… · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q13627
- Elsewhere: RCSB PDB 6UIP · PDBe 6UIP · UniProt Q13627
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