MolNFT v1 · #166057 · protein
Cryo-EM structure of the respiratory syncytial virus RNA polymerase
6UEN · RNA-directed RNA polymerase L: “Cryo-EM structure of the respiratory syncytial virus RNA polymerase”. Electron microscopy, 20 pockets (best druggability 0.78). MolNFT v1 #166057 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 6UEN
- Type
- protein
- Length
- 1,696 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA-directed RNA polymerase L; The phosphoprotein (P) of human respiratory syncytial virus
- EC
- 2.7.7.48, 2.1.1.56, 2.7.7.-, 2.7.7.88
- UniProt
- G8EJ12, G3C7Q7
- Pockets
- 20 · best druggability 0.78
Structure
electron microscopy · 5 distinct chains · 54% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RNA-directed RNA polymerase L (EC 2.7.7.48, 2.1.1.56, 2.7.7.-, 2.7.7.88) | protein | 1392 | 50% helix, 8% strand | G8EJ12 |
| B | The phosphoprotein (P) of human respiratory syncytial virus | protein | 60 | 85% helix, 0% strand | G3C7Q7 |
| C | The phosphoprotein (P) of human respiratory syncytial virus | protein | 55 | 95% helix, 0% strand | G3C7Q7 |
| D | The phosphoprotein (P) of human respiratory syncytial virus | protein | 75 | 79% helix, 0% strand | G3C7Q7 |
| E | The phosphoprotein (P) of human respiratory syncytial virus | protein | 114 | 47% helix, 8% strand | G3C7Q7 |
Pockets
20 pockets found on a 1 Å grid, 17 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 878 | 0.78 | 0.80 | 81 | empty |
| 2 | 982 | 0.76 | 0.78 | 98 | empty |
| 3 | 685 | 0.76 | 0.81 | 72 | empty |
| 4 | 446 | 0.74 | 0.84 | 48 | empty |
| 5 | 1076 | 0.72 | 0.76 | 74 | empty |
Interfaces
10 interfaces between chains.
- A–E · 2509 Ų buried · 14 hydrogen bonds · protein-protein
- A–B · 1611 Ų buried · 16 hydrogen bonds · protein-protein
- C–D · 1357 Ų buried · 4 hydrogen bonds · protein-protein
- B–C · 1171 Ų buried · 4 hydrogen bonds · protein-protein
- D–E · 746 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 6UEN · Cryo-EM structure of the respiratory syncytial virus RNA polymerase · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G8EJ12
- Every structure of UniProt G3C7Q7
- Elsewhere: RCSB PDB 6UEN · PDBe 6UEN · UniProt G8EJ12 · UniProt G3C7Q7
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