MolNFT v1 · #165966 · protein
Met tyrosine kinase inhibition enhances the antitumor efficacy of an hgf antibody
6UBW · Hepatocyte growth factor receptor: “Met tyrosine kinase inhibition enhances the antitumor efficacy of an hgf antibody”. X-ray diffraction, 2 ligands (84S, CL), 2 pockets (best druggability 0.61). MolNFT v1 #165966 on GenesisL1: 3D…
- PDB
- 6UBW
- Type
- protein
- Length
- 296 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hepatocyte growth factor receptor
- EC
- 2.7.10.1
- UniProt
- P08581
- Ligands
- 84S, CL
- Pockets
- 2 · best druggability 0.61
Structure
x-ray diffraction · 1 distinct chain · 39% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hepatocyte growth factor receptor (EC 2.7.10.1) | protein | 296 | 39% helix, 17% strand | P08581 |
Ligands and binding sites
- 84S · N-(6-{difluoro[6-(1-methyl-1H-pyrazol-4-yl)[1,2, 4]triazolo[4,3-a]pyridin-3-yl]methyl}imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide · ligand · chains A
- CL · Chloride ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 198 | 0.61 | 0.82 | 28 | 84S |
| 2 | 192 | 0.45 | 0.74 | 23 | empty |
Compared structures
- 6UBW · MET Tyrosine Kinase Inhibition Enhances the Antitumor Efficacy of an HGF Antibody · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P08581
- Elsewhere: RCSB PDB 6UBW · PDBe 6UBW · UniProt P08581
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.