MolNFT v1 · #165909 · protein
Human mcl-1 in complex with a modified bim BH3 peptide
6UA3 · Induced myeloid leukemia cell differentiation protein mcl- 1: “Human mcl-1 in complex with a modified bim BH3 peptide”. X-ray diffraction, 2 ligands (ACE, NH2). MolNFT v1 #165909 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 6UA3
- Type
- protein
- Length
- 176 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Induced myeloid leukemia cell differentiation protein mcl- 1; Modified bim BH3 peptide
- UniProt
- Q07820
- Ligands
- ACE, NH2
Structure
x-ray diffraction · 2 distinct chains · 77% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Induced myeloid leukemia cell differentiation protein mcl- 1 | protein | 155 | 77% helix, 0% strand | Q07820 |
| B | Modified bim BH3 peptide | protein | 21 | 76% helix, 0% strand | — |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
1 interface between chains.
- A–B · 983 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 modified, 1 covalent (nonstandard, covalent ligand).
Compared structures
- 6UA3 · Human Mcl-1 in complex with a modified Bim BH3 peptide · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q07820
- Elsewhere: RCSB PDB 6UA3 · PDBe 6UA3 · UniProt Q07820
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