MolNFT v1 · #165841 · protein

Apo full-length rat TRPV2 in nanodiscs, state 1

6U84 · Transient receptor potential cation channel subfamily V…: “Apo full-length rat TRPV2 in nanodiscs, state 1”. Electron microscopy, 20 pockets (best druggability 0.84). MolNFT v1 #165841 on GenesisL1: 3D structure, binding sites and…

PDB: 6U84
Type: protein
Length: 2,520 residues
Chains: 4
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transient receptor potential cation channel subfamily V member 2
UniProt: Q9WUD2
Pockets: 20 · best druggability 0.84

Structure

electron microscopy · 1 distinct chain · 55% helix, 6% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Transient receptor potential cation channel subfamily V member 2	protein	630	55% helix, 6% strand	Q9WUD2

Pockets

20 pockets found on a 1 Å grid, 17 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	814	0.84	0.86	72	empty
2	278	0.74	0.87	30	empty
3	280	0.74	0.87	30	empty
4	273	0.74	0.87	27	empty
5	270	0.74	0.87	29	empty

Interfaces

6 interfaces between chains.

C–D · 3285 Å² buried · 17 hydrogen bonds · protein-protein
A–B · 3284 Å² buried · 17 hydrogen bonds · protein-protein
A–D · 3281 Å² buried · 18 hydrogen bonds · protein-protein
B–C · 3271 Å² buried · 17 hydrogen bonds · protein-protein
B–D · 79 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

6U84 · Apo full-length rat TRPV2 in nanodiscs, state 1 · the same entry in another collection · chain A against A, TM-score 1.00
Q9WUD2 · AlphaFold monomer V2.0 prediction for transient receptor potential cation channel… · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9WUD2
Elsewhere: RCSB PDB 6U84 · PDBe 6U84 · UniProt Q9WUD2

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