MolNFT v1 · #165819 · protein
Faecalibacterium prausnitzii beta-glucuronidase
6U7I: “Faecalibacterium prausnitzii beta-glucuronidase”. X-ray diffraction, 16 pockets (best druggability 0.88). MolNFT v1 #165819 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6U7I
- Type
- protein
- Length
- 2,384 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Beta-glucuronidase
- UniProt
- A0A3F3JX71
- Pockets
- 16 · best druggability 0.88
Structure
x-ray diffraction · 3 distinct chains · 19% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Beta-glucuronidase | protein | 595 | 19% helix, 30% strand | A0A3F3JX71 |
| B, D | Beta-glucuronidase | protein | 596 | 19% helix, 31% strand | A0A3F3JX71 |
| C | Beta-glucuronidase | protein | 597 | 19% helix, 30% strand | A0A3F3JX71 |
Pockets
16 pockets found on a 1 Å grid, 15 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1125 | 0.88 | 0.89 | 94 | empty |
| 2 | 1033 | 0.86 | 0.87 | 116 | empty |
| 3 | 608 | 0.82 | 0.87 | 69 | empty |
| 4 | 949 | 0.81 | 0.83 | 117 | empty |
| 5 | 120 | 0.77 | 0.97 | 23 | empty |
Interfaces
6 interfaces between chains.
- C–D · 2233 Ų buried · 20 hydrogen bonds · protein-protein
- A–C · 2181 Ų buried · 15 hydrogen bonds · protein-protein
- A–B · 2168 Ų buried · 24 hydrogen bonds · protein-protein
- B–D · 2151 Ų buried · 25 hydrogen bonds · protein-protein
- A–D · 573 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 6U7I · Faecalibacterium prausnitzii Beta-glucuronidase · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A3F3JX71
- Elsewhere: RCSB PDB 6U7I · PDBe 6U7I · UniProt A0A3F3JX71
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