MolNFT v1 · #165790 · protein
Crystal structure of a vaccine-elicited anti-HIV-1 rhesus macaque antibody DH846
6U6O · DH846 Fab heavy chain: “Crystal structure of a vaccine-elicited anti-HIV-1 rhesus macaque antibody DH846”. X-ray diffraction, 3 pockets (best druggability 0.62). MolNFT v1 #165790 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6U6O
- Type
- protein
- Length
- 425 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DH846 Fab heavy chain; DH846 Fab light chain
- Pockets
- 3 · best druggability 0.62
Structure
x-ray diffraction · 2 distinct chains · 4% helix, 52% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | DH846 Fab heavy chain | protein | 215 | 3% helix, 53% strand | — |
| L | DH846 Fab light chain | protein | 210 | 6% helix, 51% strand | — |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 531 | 0.62 | 0.75 | 61 | empty |
| 2 | 128 | 0.45 | 0.77 | 26 | empty |
| 3 | 88 | 0.34 | 0.75 | 17 | empty |
Interfaces
1 interface between chains.
- H–L · 1916 Ų buried · 19 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 6U6O · Crystal structure of a vaccine-elicited anti-HIV-1 rhesus macaque antibody DH846 · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6U6O · PDBe 6U6O
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