MolNFT v1 · #165788 · protein

Crystal structure of a vaccine-elicited anti-HIV-1 rhesus macaque antibody DH840.1

6U6M · DH840.1 Fab heavy chain: “Crystal structure of a vaccine-elicited anti-HIV-1 rhesus macaque antibody DH840.1”. X-ray diffraction, 5 pockets (best druggability 0.56). MolNFT v1 #165788 on GenesisL1: 3D structure, binding sites and…

PDB: 6U6M
Type: protein
Length: 428 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DH840.1 Fab heavy chain; DH840.1 Fab light chain
Pockets: 5 · best druggability 0.56

Structure

x-ray diffraction · 2 distinct chains · 7% helix, 50% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
H	DH840.1 Fab heavy chain	protein	218	7% helix, 51% strand	—
L	DH840.1 Fab light chain	protein	210	7% helix, 49% strand	—

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	409	0.56	0.74	54	empty
2	94	0.33	0.73	18	empty
3	54	0.28	0.74	16	empty
4	60	0.26	0.73	13	empty
5	50	0.26	0.74	16	empty

Interfaces

1 interface between chains.

H–L · 1945 Å² buried · 12 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

6U6M · Crystal structure of a vaccine-elicited anti-HIV-1 rhesus macaque antibody DH840.1 · the same entry in another collection · chain H against H, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6U6M · PDBe 6U6M

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