MolNFT v1 · #165756 · protein
Structure of the human metapneumovirus polymerase bound to the phosphoprotein tetramer
6U5O · RNA-directed RNA polymerase L: “Structure of the human metapneumovirus polymerase bound to the phosphoprotein tetramer”. Electron microscopy, 20 pockets (best druggability 0.79). MolNFT v1 #165756 on GenesisL1: 3D structure, binding…
- PDB
- 6U5O
- Type
- protein
- Length
- 1,623 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA-directed RNA polymerase L; Phosphoprotein
- EC
- 2.7.7.48, 2.1.1.56, 2.7.7.-, 2.7.7.88
- UniProt
- Q6WB93, Q8B9Q8
- Pockets
- 20 · best druggability 0.79
Structure
electron microscopy · 5 distinct chains · 50% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | RNA-directed RNA polymerase L (EC 2.7.7.48, 2.1.1.56, 2.7.7.-, 2.7.7.88) | protein | 1354 | 47% helix, 7% strand | Q6WB93 |
| P | Phosphoprotein | protein | 98 | 52% helix, 10% strand | Q8B9Q8 |
| Q | Phosphoprotein | protein | 66 | 76% helix, 0% strand | Q8B9Q8 |
| R | Phosphoprotein | protein | 52 | 63% helix, 0% strand | Q8B9Q8 |
| S | Phosphoprotein | protein | 53 | 83% helix, 0% strand | Q8B9Q8 |
Pockets
20 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1105 | 0.79 | 0.81 | 97 | empty |
| 2 | 1108 | 0.73 | 0.76 | 61 | empty |
| 3 | 136 | 0.69 | 0.90 | 32 | empty |
| 4 | 322 | 0.68 | 0.82 | 37 | empty |
| 5 | 50 | 0.68 | 0.95 | 16 | empty |
Interfaces
10 interfaces between chains.
- L–P · 2403 Ų buried · 35 hydrogen bonds · protein-protein
- L–Q · 1635 Ų buried · 24 hydrogen bonds · protein-protein
- Q–R · 1315 Ų buried · 9 hydrogen bonds · protein-protein
- R–S · 1036 Ų buried · 5 hydrogen bonds · protein-protein
- P–Q · 676 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 6U5O · Structure of the Human Metapneumovirus Polymerase bound to the phosphoprotein tetramer · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6WB93
- Every structure of UniProt Q8B9Q8
- Elsewhere: RCSB PDB 6U5O · PDBe 6U5O · UniProt Q6WB93 · UniProt Q8B9Q8
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