MolNFT v1 · #165720 · protein
Crystal structure of IDH1 R132H mutant in complex with ft-2102
6U4J: “Crystal structure of IDH1 R132H mutant in complex with ft-2102”. X-ray diffraction, 3 ligands (NAP, PWV, CL). MolNFT v1 #165720 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6U4J
- Type
- protein
- Length
- 827 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- O75874
- Ligands
- NAP, PWV, CL
Structure
x-ray diffraction · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 415 | — | O75874 |
| B | — | protein | 412 | — | O75874 |
Ligands and binding sites
- NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · ligand · 2 copies · chains A, B
- PWV · 5-{[(1S)-1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl) ethyl]amino}-1-methyl-6-oxo-1,6-dihydropyridine-2-carbonitrile · ligand · 2 copies · chains A, B
- CL · Chloride ion · ion · 2 copies · chains A, B
- FLC · Citrate anion · additive · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6U4J · Crystal structure of IDH1 R132H mutant in complex with FT-2102 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O75874
- Elsewhere: RCSB PDB 6U4J · PDBe 6U4J · UniProt O75874
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