MolNFT v1 · #165689 · protein
Best fitting antiparallel model for volume 1 of truncated dimeric cytohesin-3 (GRP1; amino acids 14-399)
6U3E: “Best fitting antiparallel model for volume 1 of truncated dimeric cytohesin-3 (GRP1; amino acids 14-399)”. Electron microscopy, 1 ligand (4IP), 7 pockets (best druggability 0.68). MolNFT v1 #165689 on GenesisL1: 3D structure…
- PDB
- 6U3E
- Type
- protein
- Length
- 794 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cytohesin-3
- UniProt
- O43739
- Ligands
- 4IP
- Pockets
- 7 · best druggability 0.68
Structure
electron microscopy · 1 distinct chain · 47% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Cytohesin-3 | protein | 397 | 47% helix, 12% strand | O43739 |
Ligands and binding sites
- 4IP · Inositol-(1,3,4,5)-tetrakisphosphate · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 574 | 0.68 | 0.78 | 52 | empty |
| 2 | 385 | 0.66 | 0.79 | 44 | empty |
| 3 | 112 | 0.43 | 0.78 | 18 | 4IP |
| 4 | 97 | 0.42 | 0.78 | 18 | 4IP |
| 5 | 82 | 0.36 | 0.75 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 1025 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 6U3E · Best fitting antiparallel model for Volume 1 of truncated dimeric Cytohesin-3 (Grp1… · the same entry in another collection · chain A against A, TM-score 1.00
- O43739 · AlphaFold monomer V2.0 prediction for cytohesin-3 (O43739) · a predicted model of the same protein · chain B against A, TM-score 0.82
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O43739
- Elsewhere: RCSB PDB 6U3E · PDBe 6U3E · UniProt O43739
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