MolNFT v1 · #165547 · protein
Structure of KU80 von willebrand domain S229A mutant complexed with xlf ku binding motif
6TYX · X-ray repair cross-complementing protein 5: “Structure of KU80 von willebrand domain S229A mutant complexed with xlf ku binding motif”. X-ray diffraction, 4 pockets (best druggability 0.45). MolNFT v1 #165547 on GenesisL1: 3D…
- PDB
- 6TYX
- Type
- protein
- Length
- 439 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- X-ray repair cross-complementing protein 5; Lys-gly-leu-phe-met
- EC
- 3.6.4.-
- UniProt
- A0A1L8EVE5
- Pockets
- 4 · best druggability 0.45
Structure
x-ray diffraction · 4 distinct chains · 44% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | X-ray repair cross-complementing protein 5 (EC 3.6.4.-) | protein | 211 | 45% helix, 19% strand | A0A1L8EVE5 |
| B | X-ray repair cross-complementing protein 5 (EC 3.6.4.-) | protein | 216 | 43% helix, 19% strand | A0A1L8EVE5 |
| C | Lys-gly-leu-phe-met | protein | 5 | 60% helix, 0% strand | — |
| D | Lys-gly-leu-phe-met | protein | 7 | 43% helix, 0% strand | — |
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 76 | 0.45 | 0.81 | 25 | empty |
| 2 | 67 | 0.39 | 0.79 | 17 | empty |
| 3 | 94 | 0.39 | 0.76 | 25 | empty |
| 4 | 71 | 0.32 | 0.75 | 13 | empty |
Interfaces
3 interfaces between chains.
- A–C · 381 Ų buried · 2 hydrogen bonds · protein-protein
- B–D · 357 Ų buried · 2 hydrogen bonds · protein-protein
- A–B · 152 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 6TYX · Structure of Ku80 von Willebrand domain S229A mutant complexed with XLF Ku Binding Motif · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A1L8EVE5
- Elsewhere: RCSB PDB 6TYX · PDBe 6TYX · UniProt A0A1L8EVE5
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