MolNFT v1 · #165546 · protein
Structure of KU80 von willebrand domain S229A mutant complexed with aplf ku binding motif
6TYW · X-ray repair cross-complementing protein 5: “Structure of KU80 von willebrand domain S229A mutant complexed with aplf ku binding motif”. X-ray diffraction, 2 pockets (best druggability 0.50). MolNFT v1 #165546 on GenesisL1: 3D…
- PDB
- 6TYW
- Type
- protein
- Length
- 231 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- X-ray repair cross-complementing protein 5; Glu-arg-lys-arg-ile-leu-pro-thr-TRP-met-leu-al…
- EC
- 3.6.4.-
- UniProt
- A0A1L8EVE5
- Pockets
- 2 · best druggability 0.50
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | X-ray repair cross-complementing protein 5 (EC 3.6.4.-) | protein | 218 | 40% helix, 20% strand | A0A1L8EVE5 |
| B | Glu-arg-lys-arg-ile-leu-pro-thr-TRP-met-leu-ala-glu | protein | 13 | 31% helix, 0% strand | — |
Ligands and binding sites
- EDO · 1,2-ethanediol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 153 | 0.50 | 0.79 | 24 | empty |
| 2 | 77 | 0.36 | 0.77 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 751 Ų buried · 21 hydrogen bonds · protein-protein
Compared structures
- 6TYW · Structure of Ku80 von Willebrand domain S229A mutant complexed with APLF Ku Binding Motif · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A1L8EVE5
- Elsewhere: RCSB PDB 6TYW · PDBe 6TYW · UniProt A0A1L8EVE5
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