MolNFT v1 · #165445 · protein
Crystal structure of 5-bromoindoline-2,3-dione covalently bound to the pH domain of BRUTON'S tyrosine kinase
6TVN: “Crystal structure of 5-bromoindoline-2,3-dione covalently bound to the pH domain of BRUTON'S tyrosine kinase”. X-ray diffraction, 3 ligands (NYQ, ZN, MG). MolNFT v1 #165445 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 6TVN
- Type
- protein
- Length
- 615 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q06187
- Ligands
- NYQ, ZN, MG
Structure
x-ray diffraction · 4 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 160 | — | Q06187 |
| B | — | protein | 150 | — | Q06187 |
| C | — | protein | 157 | — | Q06187 |
| D | — | protein | 148 | — | Q06187 |
Ligands and binding sites
- NYQ · 5-bromanyl-1,3-dihydroindol-2-one · ligand · 4 copies · chains A, B, C, D
- ZN · Zinc ion · metal · 4 copies · chains A, B, C, D
- MG · Magnesium ion · metal · 2 copies · chains A, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6TVN · Crystal Structure of 5-bromoindoline-2,3-dione covalently bound to the PH domain of… · the same entry in another collection · chain D against D, TM-score 1.00
- Q06187 · AlphaFold monomer V2.0 prediction for tyrosine-protein kinase btk (Q06187) · a predicted model of the same protein · chain D against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q06187
- Elsewhere: RCSB PDB 6TVN · PDBe 6TVN · UniProt Q06187
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