MolNFT v1 · #165441 · protein
Selenomethionine-substituted HPF1 from nematostella vectensis
6TVH · Predicted protein: “Selenomethionine-substituted HPF1 from nematostella vectensis”. X-ray diffraction, 3 pockets (best druggability 0.71). MolNFT v1 #165441 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6TVH
- Type
- protein
- Length
- 601 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Predicted protein
- UniProt
- A7RS11
- Pockets
- 3 · best druggability 0.71
Structure
x-ray diffraction · 2 distinct chains · 51% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Predicted protein | protein | 301 | 51% helix, 9% strand | A7RS11 |
| B | Predicted protein | protein | 300 | 51% helix, 9% strand | A7RS11 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 524 | 0.71 | 0.80 | 54 | empty |
| 2 | 698 | 0.70 | 0.77 | 72 | empty |
| 3 | 101 | 0.39 | 0.76 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 871 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 20 modified, 1 disulfide (engineered, disulfide).
Compared structures
- 6TVH · Selenomethionine-substituted HPF1 from Nematostella vectensis · the same entry in another collection · chain A against A, TM-score 1.00
- A7RS11 · AlphaFold monomer V2.0 prediction for histone parylation factor 1 (A7RS11) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A7RS11
- Elsewhere: RCSB PDB 6TVH · PDBe 6TVH · UniProt A7RS11
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