MolNFT v1 · #165341 · protein
Crystal structure of tfiih subunit P52 in complex with P8
6TRS · RNA polymerase II transcription factor B subunit 2: “Crystal structure of tfiih subunit P52 in complex with P8”. X-ray diffraction, 11 pockets (best druggability 0.63). MolNFT v1 #165341 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6TRS
- Type
- protein
- Length
- 708 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA polymerase II transcription factor B subunit 2; Uncharacterized protein
- UniProt
- G0S965, G0SDQ1
- Pockets
- 11 · best druggability 0.63
Structure
x-ray diffraction · 3 distinct chains · 46% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RNA polymerase II transcription factor B subunit 2 | protein | 292 | 49% helix, 11% strand | G0S965 |
| B | RNA polymerase II transcription factor B subunit 2 | protein | 350 | 46% helix, 13% strand | G0S965 |
| D | Uncharacterized protein | protein | 66 | 36% helix, 15% strand | G0SDQ1 |
Pockets
11 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 402 | 0.63 | 0.78 | 48 | empty |
| 2 | 77 | 0.61 | 0.89 | 25 | empty |
| 3 | 312 | 0.57 | 0.77 | 38 | empty |
| 4 | 79 | 0.56 | 0.86 | 25 | empty |
| 5 | 85 | 0.53 | 0.84 | 15 | empty |
Interfaces
2 interfaces between chains.
- A–B · 2828 Ų buried · 30 hydrogen bonds · protein-protein
- B–D · 1096 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- 6TRS · Crystal structure of TFIIH subunit p52 in complex with p8 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G0S965
- Every structure of UniProt G0SDQ1
- Elsewhere: RCSB PDB 6TRS · PDBe 6TRS · UniProt G0S965 · UniProt G0SDQ1
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