MolNFT v1 · #165227 · protein

Neck of empty gta particle computed with C12 symmetry

6TO8 · Adaptor protein RCC01688: “Neck of empty gta particle computed with C12 symmetry”. Electron microscopy, 6 pockets (best druggability 0.50). MolNFT v1 #165227 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6TO8
Type: protein
Length: 542 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Adaptor protein RCC01688; Portal protein RCC01684
UniProt: D5ATZ4, D5ATZ0
Pockets: 6 · best druggability 0.50

Structure

electron microscopy · 2 distinct chains · 34% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	Adaptor protein RCC01688	protein	182	25% helix, 15% strand	D5ATZ4
A	Portal protein RCC01684	protein	360	39% helix, 11% strand	D5ATZ0

Pockets

6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	232	0.50	0.75	25	empty
2	52	0.44	0.84	20	empty
3	87	0.37	0.75	14	empty
4	83	0.36	0.76	15	empty
5	54	0.28	0.74	12	empty

Interfaces

1 interface between chains.

B–A · 60 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

6TO8 · Neck of empty GTA particle computed with C12 symmetry · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt D5ATZ4
Every structure of UniProt D5ATZ0
Elsewhere: RCSB PDB 6TO8 · PDBe 6TO8 · UniProt D5ATZ4 · UniProt D5ATZ0

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