MolNFT v1 · #165184 · protein
Cryo-EM structure of toxoplasma gondii mitochondrial ATP synthase dimer, peripheral stalk model
6TMI · ATP synthase subunit alpha: “Cryo-EM structure of toxoplasma gondii mitochondrial ATP synthase dimer, peripheral stalk model”. Electron microscopy, 6 pockets (best druggability 0.67). MolNFT v1 #165184 on GenesisL1: 3D structure…
- PDB
- 6TMI
- Type
- protein
- Length
- 605 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ATP synthase subunit alpha; Oligomycin sensitivity conferring protein (oscp); Subunit D…
- UniProt
- S7UU80, A0A125YKF8, S7V493, A0A125YKF7, S7V2T0
- Pockets
- 6 · best druggability 0.67
Structure
electron microscopy · 5 distinct chains · 65% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | ATP synthase subunit alpha | protein | 20 | 60% helix, 0% strand | S7UU80 |
| G | Oligomycin sensitivity conferring protein (oscp) | protein | 180 | 59% helix, 8% strand | A0A125YKF8 |
| A | Subunit D | protein | 109 | 70% helix, 0% strand | S7V493 |
| R | ATPTG12 | protein | 50 | 38% helix, 2% strand | A0A125YKF7 |
| B | Subunit B | protein | 246 | 73% helix, 0% strand | S7V2T0 |
Pockets
6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 127 | 0.67 | 0.88 | 34 | empty |
| 2 | 131 | 0.64 | 0.87 | 34 | empty |
| 3 | 281 | 0.62 | 0.80 | 38 | empty |
| 4 | 139 | 0.58 | 0.83 | 19 | empty |
| 5 | 75 | 0.41 | 0.79 | 22 | empty |
Interfaces
7 interfaces between chains.
- A–B · 2669 Ų buried · 19 hydrogen bonds · protein-protein
- R–B · 1997 Ų buried · 12 hydrogen bonds · protein-protein
- A–R · 1437 Ų buried · 5 hydrogen bonds · protein-protein
- G–B · 1080 Ų buried · 10 hydrogen bonds · protein-protein
- C–B · 681 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 6TMI · Cryo-EM structure of Toxoplasma gondii mitochondrial ATP synthase dimer, peripheral stalk… · the same entry in another collection · chain C against C, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt S7UU80
- Every structure of UniProt A0A125YKF8
- Every structure of UniProt S7V493
- Every structure of UniProt A0A125YKF7
- Every structure of UniProt S7V2T0
- Elsewhere: RCSB PDB 6TMI · PDBe 6TMI · UniProt S7UU80 · UniProt A0A125YKF8 · UniProt S7V493 · UniProt A0A125YKF7 · UniProt S7V2T0
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