MolNFT v1 · #16509 · protein

Anthranilate phosphoribosyl-transferase (trpd)

1O17 · Anthranilate phosphoribosyltransferase: “Anthranilate phosphoribosyl-transferase (trpd)”. X-ray diffraction, 7 pockets (best druggability 0.78). MolNFT v1 #16509 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1O17
Type: protein
Length: 1,365 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Anthranilate phosphoribosyltransferase
EC: 2.4.2.18
UniProt: P50384
Pockets: 7 · best druggability 0.78

Structure

x-ray diffraction · 4 distinct chains · 53% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Anthranilate phosphoribosyltransferase (EC 2.4.2.18)	protein	339	53% helix, 13% strand	P50384
B	Anthranilate phosphoribosyltransferase (EC 2.4.2.18)	protein	340	53% helix, 13% strand	P50384
C	Anthranilate phosphoribosyltransferase (EC 2.4.2.18)	protein	341	54% helix, 13% strand	P50384
D	Anthranilate phosphoribosyltransferase (EC 2.4.2.18)	protein	345	52% helix, 13% strand	P50384

Pockets

7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	733	0.78	0.82	67	empty
2	703	0.76	0.82	57	empty
3	697	0.74	0.80	58	empty
4	706	0.74	0.80	57	empty
5	107	0.43	0.78	18	empty

Interfaces

2 interfaces between chains.

B–C · 954 Å² buried · 5 hydrogen bonds · protein-protein
A–D · 951 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

1O17 · Anthranilate phosphoribosyl-transferase (trpd) · the same entry in another collection · chain C against C, TM-score 1.00
P50384 · AlphaFold monomer V2.0 prediction for anthranilate phosphoribosyltransferase (P50384) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P50384
Elsewhere: RCSB PDB 1O17 · PDBe 1O17 · UniProt P50384

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