MolNFT v1 · #165065 · protein
IRAK4 in complex with inhibitor
6TI8: “IRAK4 in complex with inhibitor”. X-ray diffraction, 1 ligand (NBW). MolNFT v1 #165065 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6TI8
- Type
- protein
- Length
- 1,135 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q9NWZ3
- Ligands
- NBW
Structure
x-ray diffraction · 4 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 284 | — | Q9NWZ3 |
| B | — | protein | 282 | — | Q9NWZ3 |
| C | — | protein | 285 | — | Q9NWZ3 |
| D | — | protein | 284 | — | Q9NWZ3 |
Ligands and binding sites
- NBW · ~{N},~{N}-dimethyl-4-(1-methylcyclopropyl)oxy-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[3,2-d]pyrimidine-6-carboxamide · ligand · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6TI8 · IRAK4 IN COMPLEX WITH inhibitor · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NWZ3
- Elsewhere: RCSB PDB 6TI8 · PDBe 6TI8 · UniProt Q9NWZ3
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