MolNFT v1 · #16503 · protein

Crystal structure of ribonuclease III (TM1102) from thermotoga maritima at 2.0 a resolution

1O0W: “Crystal structure of ribonuclease III (TM1102) from thermotoga maritima at 2.0 a resolution”. X-ray diffraction, 6 pockets (best druggability 0.47). MolNFT v1 #16503 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1O0W
Type: protein
Length: 477 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ribonuclease III
EC: 3.1.26.3
UniProt: Q9X0I6
Pockets: 6 · best druggability 0.47

Structure

x-ray diffraction · 2 distinct chains · 64% helix, 11% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ribonuclease III (EC 3.1.26.3)	protein	238	65% helix, 11% strand	Q9X0I6
B	Ribonuclease III (EC 3.1.26.3)	protein	239	64% helix, 12% strand	Q9X0I6

Pockets

6 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	165	0.47	0.76	17	empty
2	118	0.40	0.75	18	empty
3	74	0.33	0.75	11	empty
4	83	0.33	0.74	15	empty
5	63	0.30	0.75	20	empty

Interfaces

1 interface between chains.

A–B · 1134 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

1O0W · Crystal structure of Ribonuclease III (TM1102) from Thermotoga maritima at 2.0 A… · the same entry in another collection · chain A against A, TM-score 1.00
Q9X0I6 · AlphaFold monomer V2.0 prediction for ribonuclease 3 (Q9X0I6) · a predicted model of the same protein · chain A against A, TM-score 0.69

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9X0I6
Elsewhere: RCSB PDB 1O0W · PDBe 1O0W · UniProt Q9X0I6

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